2012 deVries

Excerpt

Cerebral small vessel disease (SVD) is an important cause of stroke, and an increasing number of single- gene disorders causing SVD have recently been identified. Of these, CADASIL (cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is most common; others such as mutations in the HtrA serine protease 1 (HTRA1) gene and the TREX1 gene have also been identified.1–3 In this issue of Annals of Neurology, Weng and colleagues4 investigated the potential role of COL4A1 mutations in patients with sporadic late onset intracerebral hemorrhage (ICH).

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Publish Date: 1 February 2012

Gould Syndrome Foundation